Clinical trials aim to minimise participant risk and generate new clinical knowledge for the wider population. Many military agencies are now investing efforts in pushing towards developing new treatments involving Brain-Computer Interfaces, Gene Therapy and Stem Cells interventions. These trials are targeting smaller disease groups, as such they give rise to novel participant risks of harms that are largely not accommodated by existing practice. This is of most concern with irreversible harms at early trial stages, where participants may forfeit any (...) future therapy, and in personalised medicine, where the individual participant assumes all of the trial risk. Given these new experimental interventions involve high risk of irreversible harms, how much risk should patients be exposed to when participating in experimental testing of innovative technologies? Designing clinical trials which better balance risk/benefit ratios for participants is crucial. The aim of this book chapter is to suggest a new stratified risk framework aimed at minimising the risk-benefit ratio to participants in clinical trials associated with high risk of irrevocable harms. We will argue it demands a higher-level of clinical data capture at earlier trial stages than predicated by current trial doctrine; it also requires publication of all trial data to minimise risk to participants of any future trial. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

In their article, Sankary et al. (2022) provided important preliminary findings on how research participants exiting from clinical trials engage in decisions related to the removal or post-trial us...

The study by Levy et al. (2024) offers new insights into clinical trial participant experience when assessing a novel visual cortical prosthesis (VCP) during an early feasibility study (EFS). We ap...

In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...) to first-in-human clinical trials involving novel technologies, the question arises as to whether it is appropriate to advocate for a new model that prioritizes efficacy over safety across all phase 1 clinical research trials involving irreversible interventions in the brain. -/- . (shrink)

James Beattie was appointed professor of moral philosophy and logic at Marischal College, Aberdeen, Scotland at the age of twenty-five. Though more fond of poetry than philosophy, he became part of the Scottish 'Common Sense' school of philosophy that included Thomas Reid and George Campbell. In 1770 Beattie published the work for which he is best known, An Essay on Truth, an abrasive attack on 'modern scepticism' in general, and on David Hume in particular, subsequently and despite Beattie's attack, Scotland's (...) most famous philosopher. The Essay was a great success, earning its author an honorary degree from Oxford and an audience with George III. Samuel Johnson declared in 1772 that 'We all love Beattie'. Hume, on the other hand, described the Essay as 'a horrible large lie in octavo', and dismissed its author as a 'bigotted silly Fellow'. Although Beattie is no match for Hume as a philosopher, the success of the Essay suggests that, unlike Hume, Beattie voices the characteristic assumptions, and anxieties, of his age. The first part of this selection—the first ever made from Beattie's prose writings—includes several key chapters from the Essay on Truth, along with extracts from all of Beattie's other works on moral philosophy. The topics treated include memory, the existence of God, the nature of virtue, and slavery. The second part of the selection is devoted to Beattie's contributions to literary criticism and aesthetics. Beattie's studies of poetry, music, taste, and the sublime are vital to the understanding of the literary culture out of which developed the early Romanticism of Wordsworth and Coleridge. (shrink)

The concept of the Anthropocene reflects a particular meaning of the “human” as it exists in society, and a specific understanding of freedom, which only became possible at the close of the twentieth century. Whereas Enlightenment thinkers such as Kant, Rousseau, and Adam Smith attempted to grasp the potential for humanity to be changed through society in a self-conscious process of attaining freedom, the “Age of Man” today appears entirely disconnected from human agency. Indeed, the Anthropocene is associated not with (...) the flourishing of life but with the sixth mass extinction. Drawing insight from classical and contemporary critical theory, this paper seeks to explicate the emancipatory potential within the concept of the Anthropocene, and the ways in which this potential is blocked by material circumstances that masquerade as “freedom.”. (shrink)

Building on recent revisionist trends, this book offers a refreshing new perspective on the Renaissance and presents an invaluable examination of continuities and discontinuities from Petrarch to Machiavelli, from Giotto to Durer, and from Italy to Burgundy, Bohemia and beyond.".

A consistent finding reported in the literature is that epistemically suspect beliefs are less frequently endorsed by individuals with a greater tendency to think analytically. However, these results have been observed predominantly in Western participants. In the present work, we explore various individual differences known to predict epistemically suspect beliefs across both Western and Eastern cultures. Across four studies with Japanese and Western individuals, we find that the association between thinking style and beliefs varied as a function of culture. Specifically, (...) while Westerners who scored higher on measures of Type-2 analytic thinking tended to endorse epistemically suspect beliefs less, this association was not observed in Japanese samples, suggesting that the often-observed negative association between analytic thinking and epistemically suspect beliefs may be exclusive to Western individuals. Additionally, we demonstrate that a tendency to think holistically is positively associated with the endorsement of epistemically suspect beliefs within both samples. Overall, we discuss how various individual differences predict the endorsement of epistemically suspect beliefs across cultures. (shrink)

At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multi-national data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from (...) social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar was found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-negligible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic. (shrink)

How does talk work, and can we engage the public in a dialogue about the scientific study of talk? This article presents a history, critical evaluation and empirical illustration of the public science of talk. We chart the public ethos of conversation analysis that treats talk as an inherently public phenomenon and its transcribed recordings as public data. We examine the inherent contradictions that conversation analysis is simultaneously obscure yet highly cited; it studies an object that people understand intuitively, yet (...) routinely produces counter-intuitive findings about talk. We describe a novel methodology for engaging the public in a science exhibition event and show how our ‘conversational rollercoaster’ used live recording, transcription and public-led analysis to address the challenge of demonstrating how talk can become an informative object of scientific research. We conclude by encouraging researchers not only to engage in a public dialogue but also to find ways to actively engage people in taking a scientific approach to talk as a pervasive, structural feature of their everyday lives. (shrink)

The classical/balance controversy continued along these lines throughout the first half of the sixties. Then, at about the same time that the classical position lost its leading advocate, the balance position received striking new support from Harry Harris, and independently from Dobzhansky's former student Lewontin, and Lewontin's research partner, Jack Hubby.80 These developments served more to reorient the controversy than to end it — and the resulting “neoclassical”/balance controversy is different enough to be grist for another mill.Social policy considerations (...) no longer play a role in keeping the dispute alive. This particular respect in which the issues have changed is, as Diane Paul suggests in her contribution to this volume, as striking as any other.82 There is, however, little danger of our forgetting that this was once much more than just a narrowly technical controversy — the additional social policy issues were far too blatant.However, although blatant, they were by no means the only, or even the most important, issues. In choosing to concentrate on the social policy considerations, I do not mean to suggest that the empirical issues were irrelevant, or simple and straightforward, or otherwise uninteresting. That is by no means the case. What I have tried to show is that there was much more to the classical/balance stalemate than just the empirical underdetermination of the theoretical issues, and that the empirical issues cannot be treated adequately without taking into account the social policy considerations that were involved. Dobzhansky and Muller both appealed to the dangers of misguided social policy that might have resulted from prematurely resolving their controversy in the other's favor. They called for high empirical standards on those grounds, more than once seeking to forestall the resolution of their dispute in this way. (shrink)

Since the seventeenth century, when Descartes divided the universe into two realms, the distinctive character of one of which being its spatiality or extendedness, philosophers have been increasingly concerned with the analysis of the category of Space. Scientists, too, have been interested in the concepts of Space and Time, especially since the promulgation of the theory of relativity.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Alexander Zambrano sets out to refute an argument that I have made on a number of occasions over many years since 1992, which he calls “Harris’s Greater Need Argument” (2002).

Philosophy was at the core of the eighteenth century movement known as the Scottish Enlightenment. The movement included major figures, such as Francis Hutcheson, David Hume, Adam Smith, Thomas Reid and Adam Ferguson, and also many others who produced notable works, such as Gershom Carmichael, George Turnbull, George Campbell, James Beattie, Alexander Gerard, Henry Home (Lord Kames) and Dugald Stewart. I discuss some of the leading ideas of these thinkers, though paying less attention than I otherwise would to Hume, (...) Smith and Reid, who have separate Encyclopedia entries. Amongst the topics covered in this entry are aesthetics (particularly Hutcheson's), Moral philosophy (particularly Hutcheson's and Smith's), Turnbull's providential naturalism, Kames's doctrines on divine goodness and human freedom, Campbell's criticism of the Humean account of miracles, the philosophy of rhetoric, Ferguson's criticism of the idea of a state of nature, and finally the concept of conjectural history, a concept especially associated with Dugald Stewart. (shrink)

James A. Harris - The Cambridge Companion to the Scottish Enlightenment - Journal of the History of Philosophy 44:3 Journal of the History of Philosophy 44.3 479-480 Alexander Broadie, editor. The Cambridge Companion to the Scottish Enlightenment. Cambridge-New York: Cambridge University Press, 2003. Pp. xvi + 366. Cloth, $65.00. A Cambridge Companion can be expected to attempt to do two different things at the same time: to provide a clear and concise introduction to the existing scholarly literature on all (...) the principal topics discussed by the philosopher or school of philosophy to which the Companion is devoted; and to advance the discussion in ways that will be of interest to those already working in the field. Alexander Broadie's Cambridge Companion to the Scottish Enlightenment succeeds admirably at both tasks. Excellent introductions are provided.. (shrink)

Harry van der Linden's review of: Welfare in the Kantian State. By Alexander Kaufman. Oxford: Oxford University Press, 1999. Pp.xii, 179. ISBN 0-19-829467-0. £42.50, $45.00.

In the insightful and searching paper of Mills and Beatty the following definition of ‘fitness’, as the term figures in the theory of natural selection, is offered:The [individual] fitness of an organism x in environment E equals n =dfn is the expected number of descendants which x will leave in E.

In several places we have argued that ‘fitness’ is a primitive term with respect to the theory of evolution properly understood. These arguments have relied heavily on the axiomatization of the theory provided by one of us. In contrast, both John Beatty and Robert Brandon have separately argued for a “propensity“ interpretation of “fitness” ; and in Brandon and Beatty they attack our view that “fitness“ is a primitive term in evolutionary theory, concluding that a definition by way (...) of propensities is possible and preferable. Here we reply to their criticisms, and argue that, at most, the view that fitness is a statistical propensity is a terminological variant on our thesis that it is a primitive in evolutionary theory. (shrink)

Violent video games (VVGs) are a source of serious and continuing controversy. They are not unique in this respect, though. Other entertainment products have been criticized on moral grounds, from pornography to heavy metal, horror films, and Harry Potter books. Some of these controversies have fizzled out over time and have come to be viewed as cases of moral panic. Others, including moral objections to VVGs, have persisted. The aim of this paper is to determine which, if any, of (...) the concerns raised about VVGs are legitimate. We argue that common moral objections to VVGs are unsuccessful, but that a plausible critique can be developed that captures the insights of these objections while avoiding their pitfalls. Our view suggests that the moral badness of a game depends on how well its internal logic expresses or encourages the players’ objectionable attitudes. This allows us to recognize that some games are morally worse than others—and that it can be morally wrong to design and play some VVGs—but that the moral badness of these games is not necessarily dependent on how violent they are. (shrink)

Harry G. Frankfurt’s work on agency and reflexivity represents one of the most important attempts in the current philosophical literature to elaborate the structure of agency. Frankfurt wishes to provide an account of what I call the “deep structures” of agency—those features of agency, such as care and love, in virtue of which the surface features, such as desire, are to be explained and understood. These deep structures are important because of their power to explain unified diachronic patterns in (...) our lives rather than just individual actions. In doing so, Frankfurt seeks to be a Humean in Aristotelian clothing: he desires the richness of a broadly Aristotelian moral psychology–specifically, an Augustinian variant of this—built out of the resources of a Humean human nature in which the “passions,” or here, those objects we care about, are fundamental. -/- Thus Frankfurt develops concepts such as second-order desire, identification and dissociation, wholeheartedness, and love without incurring significant metaphysical costs. Through these concepts Frankfurt provides an account with extraordinary richness. However, I argue that Frankfurt’s minimalism conflicts with his attempts to provide so rich an account of our moral lives. In particular, his attempt to make caring foundational for practical reason undermines his conception of identification and dissociation. Frankfurt’s Humeanism commits him to a tragic moral universe in which the dissociation of desire is little more than an exercise in self-deception rather than a means of guaranteeing psychic unity. -/- I then argue that a superior account of moral life and the moral self can be constructed through greater reliance upon Augustinian ideas concerning the nature of love that is rooted in two concepts: affinity and peace. The concept of affinity provides a basis for evaluating what is worth loving and the concept of peace, central to Augustine’s moral psychology, is used to analyze the structure of love itself in its many manifestations. This account is less minimalist than Frankfurt’s but is more faithful to our moral experience and provides a more powerful and nuanced analysis of moral life and the self. (shrink)

Before committing suicide, Othello says, "Speak of me as I am; . . . speak of one who loved not wisely, but too well." Thinking of his love for Desdemona, we are not likely to agree with his assessment that he loved her "too well," especially if loving well is supposed to require some kind of dependability or concern for her well-being; we would be loath even to grant that he loved her "too much." Othello's love for his wife seems, (...) rather, to have been firmly subordinated to his love for his honor. Perhaps, then, his statement could be saved by saying that it was his honor that he loved too well, and that in devoting himself so completely to it, he did not love wisely. He needed a better way of coordinating his two concerns, one that wouldn't give him cause for regret—a way of loving well that was also wise. (shrink)

The Library of Scottish Philosophy: Volumes 1 – 6, Exeter: Imprint Academic, 2004 James Otteson , ed. Adam Smith: Selected Philosophical Writings, 247pp. Paperback £12.95. ISBN 184540-001-1 James Harris , ed. James Beattie: Selected Philosophical Writings, 204pp. Paperback £12.95. ISBN 0907845-711 David Boucher , ed. The Scottish Idealists: Selected Philosophical Writings, 201pp. Paperback £12.95. ISBN 0907845-72X Jonathan Friday , ed. Art and Enlightenment: Scottish Aesthetics in the 18th century, 212pp. Paperback £12.95. ISBN 0907845-762 Gordon Graham , ed. Scottish Philosophy: Selected (...) Writings 1690–1960, 253pp. Paperback £12.95. ISBN 0907845-746 Esther McIntosh , ed. John Macmurray: Selected Philosophical Writings, 198pp. Paperback £12.95. ISBN 0907845-738. (shrink)

1. On 30th July 2021, the historian of philosophy Michael Alexander Stewart, ‘Sandy’ for colleagues and friends, died peacefully, leaving unfinished the redaction of a volume in which he intended t...

John Beatty (1995) and Alexander Rosenberg (1994) have argued against the claim that there are laws in biology. Beatty's main reason is that evolution is a process full of contingency, but he also takes the existence of relative significance controversies in biology and the popularity of pluralistic approaches to a variety of evolutionary questions to be evidence for biology's lawlessness. Rosenberg's main argument appeals to the idea that biological properties supervene on large numbers of physical properties, but (...) he also develops case studies of biological controversies to defend his thesis that biology is best understood as an instrumental discipline. The present paper assesses their arguments. (shrink)

This article elucidates a unique metaethical theory implicit in the work of several thinkers associated with the Stone-Campbell Restoration Movement. After positioning that theory within a broader landscape of metaethical positions endorsed by several prominent contemporary Christian philosophers and theologians, we address the concern that, when attending to the Euthyphro dilemma, the Restoration-inspired combination metaethical theory inevitably collapses into either an unalloyed divine command theory or an unalloyed natural law theory. In explaining how this sort of worry can be mitigated, (...) we offer reason to think that the nonreductive, combination metaethical theory in question constitutes potentially fertile territory for further scholarly work in Christian ethics. (shrink)

If consciousness emerges into ontological reality at some point in nature, as system complexity increases, then it also ‘submerges’ at some adjoining point, as structures simplify. This has led some to posit a ‘latent-consciousness’ in what Bohr saw as the consciousness-like spontaneity of quantum phenomena. Yet to move on this basis to Whitehead's ontological pan-experientialism or to direct quantum explanations of consciousness faces serious epistemological limitations -- perhaps being more unwittingly projective than genuinely explanatory. More reasonable would be an epistemological (...) pan- experientialism in the sense of the later James. Consciousness, as the ultimate lens and medium of all knowledge, is inseparable from the physical reality it would know, especially at the very limits of empirical observation in microphysics. ‘Submerged’ consciousness is better understood in Jamesian pragmatic terms than via assumed but unprovable ontologies. (shrink)